| 摘要 |
A method and apparatus is described that facilitates appropriate placement of a closure device and allows ease of placement with repeated access without bleeding. A suitable biocompatible polymer diaphragm such as silicone or nipple is place on the adventitia of the vessel through a small cutdown incision. The puncture surface is a diaphragm that functions as a self-sealing valve. For embodiments designed for small catheter access such as 4 to 9 Fr, this may be a polymer that elastically seals around the puncture once the catheter is removed. Especially for larger access catheters, such as 10 French to 24 French, a preformed aperture or slit may be cut into the material, allowing controlled and atraumatic penetration of the device and artery. The sealing element may also be fixed to the outside wall of the vessel with holdfasts through a method that facilitates percutaneous delivery through the use of a guiding wire. A method and apparatus is also described that minimizes the potential migration of emboli generated upstream from the access site, an anchoring cannula and method for facilitating localizing of the access device.
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