METHOD FOR PREVENTION OF AGE-RELATED MACULAR DEGENERATION (AMD)

摘要

A method of prevention of age-related macular degeneration (AMD) involves, in a first step, taking a sample from an individual and detecting the presence of a polymorphism (rsl 1200638 or rs 10490924, or an SNP related to or associated with a (high temperature requirement) serine protease). In a second step the individual is provided with a substance that can prevent AMD, or can mitigate or alleviate symptoms of AMD. The substance is a medication comprising lutein and/or zeaxanthin and/or certain antioxidants (or a mixture thereof) is tailored to that individual. The invention also provides a method of determining the substance to be administered to an individual, which individual may be susceptible of having age-related macular degeneration (or an age-related macular degeneration-related disorder) by detecting the presence of the polymorphism and identifying a substance capable of preventing or treating age-related macular degeneration in that individual. The method may additionally comprise providing (such as administering or communicating) the substance (or its identity) to the individual.