| 摘要 |
FIELD: medicinal industry, pharmacy. SUBSTANCE: composition for preparing an antiulcer agent as tablets has the following components, wt.-%: ranitidine, 53.3-59.4; polyvinylpyrrolidone, 1.4-2.0; magnesium stearate, 0.5-1.2; and microcrystalline cellulose, the balance. Tablets of the new agent are prepared by mixing powder-like ranitidine and microcrystalline cellulose. Mixture is wetted with polyvinylpyrrolidone an aqueous-alcohol solution followed by wetting granulation at polyvinylpyrrolidone an aqueous-alcohol solution spraying over fluidized mass. Granulate is dried, powdered with magnesium stearate and tabletted. Components mixture is wetted at 25-32 C in the boiling layer and granulate is powdered at 30-36 C. For components mixture wetting 5-6-% solution of polyvinylpyrrolidone in the mixture of water and 96% ethyl alcohol at ratio 1:(3.4-5.0) is used. Tablets of an antiulcer agent provide high bioavailability of ranitidine. New method of tablets preparing is carried out in a single unit that ensures to exclude the stage of dry granulation. EFFECT: simplified technology, enhanced availability of drug. 4 cl, 1 tbl, 1 ex |
