Time-specific delayed/pulsatile release dosage forms

摘要

A time - specific delayed/pulsatile release dosage form which comprises: · a core comprising at least one active principle and at least one disintegrating agent; · a sealing layer surrounding the core essentially consisting of one or more water soluble or water insoluble pH independent polymers; · an outer coating essentially consisting of one or more hydrophilic pH independent polymers;
wherein:
the at least one disintegrating agent is present in amounts of 1-20% by weight and
the at least one active principle is present in amounts of 1-80% by weight, with respect to the core;
the sealing layer accounts for 0.1-10% by weight, with respect to the core;
the outer coating accounts for 5-500 % by weight, with respect to the core. These coated cores are capable of ensuring the immediate release of the active principle after a pre-defined lag time, independently of physiological pH variations occurring in the gastro-intestinal tract of mammals.