发明名称 Materials and methods for immune system stimulation
摘要 The subject invention concerns a novel polysaccharide. RR1 is an alpha-D-glucan polysaccharide composed of a (1->4) linked back bone and (1->6) linked branches, which has been isolated from a medicinal herb, Tinospora cordifolia. RR1 exhibits unique immune-stimulating properties, is non-cytotoxic, and non-proliferating to normal lymphocytes, as well as tumor cell lines. The subject invention also concerns compositions containing an RR1 compound and methods for modulating an immune response in a subject using RR1 compounds. The present invention also provides methods for the use of an RR1 compound in conjunction with an antigen to stimulate an immune response, the RR1 compound providing an adjuvant-like activity in the generation of a Th1-type immune response to the antigen.
申请公布号 US7425548(B2) 申请公布日期 2008.09.16
申请号 US20050178620 申请日期 2005.07.11
申请人 VARIETY CHIDREN'S HOSPITAL 发明人 NAIR P.K. RAVEENDRAN;MELNICK STEVEN J.;RAMACHANDRAN CHEPPAIL
分类号 A61K31/716;C07H1/08;C08B37/00 主分类号 A61K31/716
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