POTENTIATION OF ANTINEOPLASTIC AGENTS USING SIGMA-2 LIGANDS

摘要

The present invention relates to the use of sigma-2 agonists to potentiate the activity of antineoplastic agents. These substances are useful for treating cancerous tumors and, in particular, drug resistant tumors in humans. Methods for sensitizing multidrug resistant cells to antitumor agents comprising contacting the cells with a sigma-2 agonist are also described.