TRANSFORMED STRAIN DERIVED FROM STRAIN DEFICIENT IN MULTIDRUG EFFLUX PROTEIN, AND BIOCONVERSION METHOD USING THE SAME

摘要

Disclosed is a means for improving the poor conversion efficiency in a conventional bioconversion using a transformant having a gene derived from a heterogeneous organism integrated therein. A microorganism having the deletion of a gene encoding a multidrug efflux protein is used as a host to produce a transformant having a gene derived from a heterogeneous organism integrated therein. By using the transformant in bioconversion, it becomes possible to convert a hydrophobic or amphipathic substrate compound into a desired compound with extremely high efficiency. When an E. coli cell is used as a host, the gene encoding multidrug efflux protein to be deleted may be tolC, acrA, acrB or the like.