发明名称 |
Method of modulating vascularization |
摘要 |
A method of modulating vascularization in a tissue of a mammal comprises controlling a PAR signaling pathway (e.g., the PAR-1 or PAR-2 signaling pathway) in a mammalian tissue, for example, by controlling phosphorylation of tissue factor cytoplasmic domain (i.e., phosphorylation of Ser<SUP>258 </SUP>of the cytoplasmic tail of TF). In a preferred method pathological is treated by administering to a mammal suffering from pathological neovascularization, a therapeutically effective amount of a PAR signaling pathway inhibitor. Preferably the mammal is a human. |
申请公布号 |
ZA200608490(B) |
申请公布日期 |
2008.08.27 |
申请号 |
ZA20060008490 |
申请日期 |
2006.10.11 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
FRIEDLANDER, MARTIN;DORRELL, MICHAEL;RUF, WOLFRAM;BELTING, MATTIAS |
分类号 |
A61K |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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