| 发明名称 |
ANTIBODIES SPECIFIC FOR DKK-1 |
| 摘要 |
<p>Antibodies specific for Dkk-1, an inhibitor of the osteoanabolic Wnt/LRP5 signaling pathway, are described. The antibodies, which inhibit binding of Dkk-1 to LRP5, are useful in compositions for stimulating bone growth, in pa rticular, compositions for treating bone disorders which result in a loss in bone, for example, osteoporosis.</p> |
| 申请公布号 |
CA2677356(A1) |
申请公布日期 |
2008.08.14 |
| 申请号 |
CA20082677356 |
申请日期 |
2008.02.04 |
| 申请人 |
MERCK & CO., INC. |
发明人 |
CHEN, FANG;WANG, FUBAO;RESZKA, ALFRED A.;FISHER, JOHN E.;KIMMEL, DONALD B.;GLANTSCHNIG, HELMUT;AN, ZHIQIANG |
| 分类号 |
C07K16/18;A61K39/395;A61P19/00 |
主分类号 |
C07K16/18 |
| 代理机构 |
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代理人 |
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| 地址 |
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