NOVEL ANTAGONISTS OF THE GLUCAGON RECEPTOR

摘要

The present invention provides for novel compounds of Formula (I) and pha rmaceutically acceptable salts and co-crystals thereof which have glucagon r eceptor antagonist or inverse agonist activity. The present invention furthe r provides for pharmaceutical compositions comprising the same as well as me thods of treating, preventing, delaying the time to onset or reducing the ri sk for the development or progression of a disease or condition for which on e or more glucagon receptor antagonist is indicated, including Type I and II diabetes, insulin resistence and hyperglycemia. The present invention also provides for processes of making the compounds of Formula I, including salts and co-crystals thereof, and pharmaceutical compositions comprising the sam e.