PAS-FLAGELLIN FUSION PROTEIN WITH IMPROVED TOLL-LIKE RECEPTOR 5 STIMULATING ACTIVITY

摘要

A PAS-flagellin recombinant fusion protein is provided to improve toll-like receptor-5(TLR5) stimulating activity by inhibiting polymerization of flagellin molecules, thereby enhancing the unique flagellin activity. A plasmid for producing a PAS-flagellin recombinant fusion protein includes a PAS gene of SEQ ID : NO. 1 and a flagellin gene of SEQ ID : NO. 3 and has a linkage map depicted in Fig. 1. A PAS-flagellin recombinant fusion protein is produced by the plasmid and is described as SEQ ID : NO. 6. A vaccine adjuvant comprises the PAS-flagellin recombinant fusion protein as an effective ingredient.