3-Triazolylthiaalkyl-3-Azabicyclo (3-1-O) Hexanes and Their Use as Dopamine D3 Receptor Ligands

摘要

The present invention relates to novel compounds of formula (I) or a pharmaceutically acceptable salt thereof: wherein R₁ is hydrogen or C_1-4alkyl; R₂ is C_1-4alkyl; R₃ is hydrogen, or a phenyl group, a heterocyclyl group, a 5- or 6-membered heteroaromatic group, or a 8- to 11-membered bicyclic group, any of which groups is optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, C_1-4alkyl, haloC_1-4alkyl, C_1-4alkoxy, C_1-4alkanoyl and SF₅; p is 0, 1, 2, 3 or 4; and R₄ is independently selected from a group consisting of: halogen, hydroxy, cyano, C_1-4alkyl, haloC_1-4alkyl, C_1-4alkoxy, haloC_1-4alkoxy and C_1-4alkanoyl; n is 0 or 1; wherein when R₄ is chlorine and p is 1, such R₄ is not present in the ortho position with respect to the linking bond to the rest of the molecule; and wherein, if n is 0, R₃ comprises at least one SF₅ group as a substituent; processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as modulators of dopamine D₃ receptors, e.g. to treat drug dependency, as antipsychotic agents, to treat obsessive compulsive spectrum disorders, premature ejaculation or cognition impairment.