发明名称 |
Interferon alpha-induced pharmacodynamic markers |
摘要 |
<p>A method of monitoring disease progression of a patient receiving treatment with a therapeutic agent that binds to and modulates IFN± activity comprising: obtaining a first IFN±-inducible PD marker expression profile in a first sample from the patient; administering a therapeutic agent that binds to and modulates IFN± activity; obtaining a second IFN±-inducible PD marker expression profile in a second sample from the patient; and comparing the first and the second IFN±-inducible PD marker expression profiles, wherein a variance in the first and the second IFN±-inducible PD marker expression profiles indicates a level of efficacy of the therapeutic agent that binds to and modulates IFN± activity.</p> |
申请公布号 |
AU2007327995(A1) |
申请公布日期 |
2008.06.12 |
申请号 |
AU20070327995 |
申请日期 |
2007.12.06 |
申请人 |
MEDIMMUNE, LLC |
发明人 |
PETER KEINER;ANTHONY COYLE;YIHONG YAO;RICARDO CIBOTTI;BAHIJA JALLAL |
分类号 |
A61K39/395;C07K16/00;C07K16/24 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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