FAMILY OF IMMUNOMODULATORS DESIGNATED LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTORS (LIR)

摘要

PROBLEM TO BE SOLVED: To provide a new family of immunoreceptor molecules of an immunoglobulin superfamily, leukocyte immunoglobulin-like receptor (LIR) polypeptides.

SOLUTION: Disclosed are sequences encoding LIR family members and their deduced amino acid sequences, polypeptides encoded by DNA that hybridize to oligonucleotide probes having defined sequences, processes for producing polypeptides of the LIR family, and antagonistic antibodies to LIR family members. LIR family members can be used to treat autoimmune diseases and disease states associated with suppressed immune function.

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