| 摘要 |
This invention provides a film coated solid oral dosage form. The coated form comprises a solid core and at least two separately applied coatings or layers. The first layer, which is a seal coat, contains a swellable polymer, such as hydroxypropyl methyl cellulose. The second layer, which is a releas e coat, contains carrageenan, microcrystalline cellulose, hydroxypropyl meth yl cellulose, and taste modifying agents. In an embodiment the coating conta ins readily releasable volatile and non-volatile flavoring and cooling agent s together with sweeteners, to provide an intense cooling effect which is in stantly perceived by the consumer upon placing the dosage form in the oral c avity.
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