Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity

摘要

The present application describes modulators of MCP-1 of formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, wherein X, Z, a, b, c, d, n, R¹, R², R³, R⁴, R⁵, R¹⁰, R^10a, and R¹², are as defined herein. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis using modulators of formula (I) are disclosed.