NOVEL 1,2-DIHYDROQUINOLINE DERIVATIVE HAVING SUBSTITUTED PHENYLAMINO LOWER ALKYL GROUP AND ESTER-INTRODUCED PHENYL GROUP AS SUBSTITUENTS

摘要

Disclosed is a novel 1,2-dihydroquinoline derivative represented by the g eneral formula (1) below, which has a substituted phenylamino lower alkyl gr oup and a phenyl group having an ester structure introduced therein as subst ituents, or a salt of such a derivative. The compound (1) or a salt thereof is useful as a glucocorticoid receptor modulator. In the formula below, R1 r epresents a hydrogen atom or a lower alkyl group; R2 represents a hydrogen a tom or a lower alkyl group; R3 and R4 may be the same or different and repre sent a hydrogen atom or a lower alkyl group; R5 represents a hydrogen atom o r a lower alkyl group; R6 represents a halogen atom, a lower alkyl group, a hydroxy group, a lower alkoxy group, a nitro group or a cyano group; X repre sents -C(O)-, -C(O)NR8-, -S(O)2- or the like; R7 and/or R8 may be the same o r different and represent a hydrogen atom, an optionally substituted lower a lkyl group, an optionally substituted aryl group, an optionally substituted heterocyclic group, an optionally substituted lower alkoxy group or the like ; Y represents a lower alkylene group; and p represents 0, 1, 2 or 3.