发明名称 |
Recombinant mycobacteria overexpressing D-alanine ligase gene and uses therefore |
摘要 |
Recombinant mycobacterial strains which overproduce essential biosynthetic enzymes of pathogenic mycobateria are provided. These strains overproduce enzymes involved in the synthesis and incorporation of <SMALLCAPS>D</SMALLCAPS>-alanine into mycobacterial peptidoglycan, the backbone of the mycobacterial cell wall. These overproducing strains may be used as reference strains in in vitro screening methods to identify antimycobacterial agents.
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申请公布号 |
US7371571(B2) |
申请公布日期 |
2008.05.13 |
申请号 |
US20030738938 |
申请日期 |
2003.12.17 |
申请人 |
BOARD OF REGENTS UNIVERSITY OF NEBRASKA - LINCOLN |
发明人 |
BARLETTA RAUL G.;FENG ZHENGYU |
分类号 |
C12N15/00;A61K39/04;C07H21/04;C07K14/00;C12N1/21;C12N9/00;C12P21/06;C12Q1/00;C12Q1/18 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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