| 摘要 |
A target delivery method of an anti-cancer drug is provided to increase in vivo retention time and selectivity to cancer cells by increasing molecular weight with LDH(layered double hydroxide), minimize side effects and maximize drug effects by controlling the size of LDH nanoparticles, selectively delivering the drug to cancer cells, and promoting cell entrance and delivery by endocytosis. A method for inhibiting growth of cancer cells selectively comprises the steps of: regulating the size of metal layered double hydroxide(LDH) to 50-450 nm and inserting an anti-cancer drug MTX(methotrexate) between layers of the LDH through ion exchange to prepare a MTX/LDH hybrid; and administering the MTX/LDH hybrid to a cancer patient through injection, wherein the cancer cell is MNNG/HOS(N-methyl-N'-nitro-N-nitroso-guanidine/human osteosarcoma).
|
