| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a method for examining a structure that is labeled, at high spatial resolution, by fluorogenic material of a specimen. <P>SOLUTION: The method for examining the structure that is labeled, at a high spatial resolution, by a fluorogenic material of the specimen and that can repeatedly convert the fluorogenic material, from a first state into a second that are mutually different states regarding at least one optical characteristic includes a step of initially setting a substance to be detected within a specimen region in the first state; and a step of inducing the second state, in a manner of controlling small regions that are spatially divided by an optical signal within the specimen region. A ligand complex (1), containing the fluorogenic material, is bonded to an enzyme (4) through an enzyme reaction inside a cell; and based on the fact that the enzyme (4) is developed as a fusion protein (6), together with a target protein (5), the protein within the living cell i.e. the target protein (5) is defined by being used as a structure labeled by the fluorogenic material. <P>COPYRIGHT: (C)2008,JPO&INPIT</p> |
