Culture substrate with an oxidized silicon surface

摘要

Solid culture substrate comprises a surface with a coating made of material like oxidized silicones and a nanoporosity of surface. The coating has a nanostructural and/or nanorugosity of surface. Independent claims are included for: (1) a process of preparing the culture substrate comprising depositing an organosilicate precursor mixed with oxygen by plasma-enhanced chemical vapor deposition (PECVD) on the substrate to form, or depositing a coating i.e. more organic and not very crosslinkable type like an organosilicate precursor mixed with a neutral gas by PECVD, treating the coating with a plasma of neutral gas or reducing under the conditions enhancing the gaseous space generation within the material to form the nanoporosity and nanorugosity; and (2) a culturing process for making living biomolecules to grow comprising contacting the substrate with the living biomolecules and a growth culture medium.