TOPIRAMATE COMPOSITIONS AND METHODS OF ENHANCING ITS BIOAVAILABILITY
摘要
<p>The present invention is directed to pharmaceutical compositions that allow for once- daily or alternate day dosage forms of topiramate. The proposed delayed/extended release single dosage form is equivalent to the immediate-release multiple dose daily regimen, and upon administration, provides steady state blood levels of topiramate. Formulations with increased bioavailability and improved pharmacokinetics are disclosed. A once-a-day administration of topiramate is advantageous over the multiple dose regimen both in terms of patient compliance and reduced adverse events, thus providing better treatment of the conditions for which the topiramate is indicated.</p>
申请公布号
WO2008027557(A2)
申请公布日期
2008.03.06
申请号
WO2007US19208
申请日期
2007.08.31
申请人
SPHERICS, INC.;NANGIA, AVINASH;VERMA, DAYA, D.;JACOB, JULES;GRANDOLFI, GEORGE, P.;CARDOSO, NICHOLAS
发明人
NANGIA, AVINASH;VERMA, DAYA, D.;JACOB, JULES;GRANDOLFI, GEORGE, P.;CARDOSO, NICHOLAS