| 摘要 |
PROBLEM TO BE SOLVED: To provide an efficient method for producing 2-trifluoromethylindoles. SOLUTION: The N-(1,1,1-trifluoro-2-propylidene)anilines and/or 2-trifluoromethylindoles expressed by general formula (3) [wherein, R<SP>1</SP>to R<SP>4</SP>are each independently H, a 1-4C alkyl, a 2-4C alkenyl, a 2-4C alkynyl, a 1-4C alkoxy, a 2-5C acyl, a (1-4C alkoxy)carbonyl, a (1-4C alkyl)amino, a di (1-4C alkyl)amino, cyano, hydroxy or a halogen atom; and X is bromine or iodine] are produced by reacting 2-brominated or 2-iodinated anilines with 2-bromo-3,3,3-trifluoropropene in the presence of a palladium catalyst and a base. COPYRIGHT: (C)2008,JPO&INPIT
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