摘要 |
This application describes the discovery that, in a pregnant woman, certain genes (such as RASSF1A, APC, CASP8, RARB, SCGB3A1, DAB21P, PTPN6, THY1, TMEFF2, and PYCARD) originated from a fetus are highly methylated, whereas the same genes of maternal origin are unmethylated. This discovery allows the easy detection of one or more of these methylated fetal genes in a biological sample from a pregnant woman, serving as a universal indicator of the presence of fetal DNA in the sample. These fetal methylation markers are particularly useful as positive controls for a non-invasive analytical process during which the quality and quantity of fetal DNA are monitored. These newly identified fetal markers can also be measured directly for diagnosis of certain pregnancy-related conditions. |
申请人 |
THE CHINESE UNIVERSITY OF HONG KONG;LO, YUK MING, DENNIS;CHIU, ROSSA WAI KWUN;CHIM, STEPHEN SIU CHUNG;DING, CHUNMING;CHAN, KWAN CHEE;WONG, HING NAM IVY;YUEN, KA CHUN RYAN |
发明人 |
LO, YUK MING, DENNIS;CHIU, ROSSA WAI KWUN;CHIM, STEPHEN SIU CHUNG;DING, CHUNMING;CHAN, KWAN CHEE;WONG, HING NAM IVY;YUEN, KA CHUN RYAN |