发明名称 |
OLIGORIBONUCLEOTIDES AND METHODS OF USE THEREOF FOR TREATMENT OF FIBROTIC CONDITIONS AND OTHER DISEASES |
摘要 |
<p>The invention relates to a double-stranded compound, preferably an oligoribonucleotide (siRNA), which down-regulates the expression of a human TGaseII gene at the post-transcriptional level. The invention also relates to a pharmaceutical composition comprising the compound, or a vector capable of expressing the oligoribonucleotide compound, and a pharmaceutically acceptable carrier. The present invention also contemplates a method of treating a patient suffering from a fibrotic disease such as pulmonary, kidney and liver fibrosis or ocular, scarring comprising administering to the patient the pharmaceutical composition in a therapeutically effective dose so as to thereby treat the patient. The invention also relates to treatment of fibrotic and other diseases by use of antibodies to TGaseII polypeptide.</p> |
申请公布号 |
EP1758998(A4) |
申请公布日期 |
2008.02.20 |
申请号 |
EP20050703145 |
申请日期 |
2005.01.27 |
申请人 |
QUARK PHARMACEUTICALS, INC. |
发明人 |
MOR, ORNA;FEINSTEIN, ELENA |
分类号 |
C07H21/04;A61K31/70;A61K48/00;C07K14/705;C07K16/18;C07K16/40;C12N9/10;C12N15/113;C12Q1/68 |
主分类号 |
C07H21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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