发明名称 |
COMPOSITIONS AND METHODS FOR MODULATING CELLS VIA CD14 AND TOLL-LIKE RECEPTOR 4 SIGNALING PATHWAY |
摘要 |
Compositions and methods are provided for screening and identifying compounds which modulate signaling of toll-like receptor 4 (TLR4) pathway via CD 14 and a ligand. Methods are provided for treatment of various disease states such as inflammation or autoimmune disease in mammalian subjects by modulating toll-like receptor 4 (TLR4) pathway signaling via CD 14 and a ligand. Transgenic non-human animals and methods for developing transgenic non-human animals are provided wherein the transgenic non-human animals comprise a loss-of-function mutation in the CD 14 gene.
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申请公布号 |
KR20080012928(A) |
申请公布日期 |
2008.02.12 |
申请号 |
KR20077028095 |
申请日期 |
2007.11.30 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
BEUTLER BRUCE;JIANG ZHENGFAN |
分类号 |
A61K39/42;A61K39/395;A61K48/00 |
主分类号 |
A61K39/42 |
代理机构 |
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代理人 |
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地址 |
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