| 发明名称 |
PROPIONIC ACID DERIVATIVES INHIBITING INTEGRINS BINDING TO RECEPTORS THEREOF, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AND USE THEREOF |
| 摘要 |
<p>The invention relates to propionic acid derivatives inhibiting the integrins binding to the receptors thereof, such as VCAM-1 (molecule of type 1 of vascular cellular adhesion) and fibronectin, to a pharmaceutical composition containing the same, as well as to the use of the mentioned derivatives for preparing a medicine for selective inhibition, in mammals, of alpha4beta1 integrin binding.</p> |
| 申请公布号 |
RO121640(B1) |
申请公布日期 |
2008.01.30 |
| 申请号 |
RO20010001209 |
申请日期 |
2000.05.05 |
| 申请人 |
TEXAS BIOTECHNOLOGY CORPORATION |
发明人 |
BIEDIGER RONALD J.;HOLLAND GEORGE W.;KASSIR JAMAL M.;LI WEN;MARKET ROBERT V.;SCOTT IAN L.;WU CHENGDE |
| 分类号 |
C07C217/48;C07D229/00;A61K31/138;A61K31/192;A61K31/33;A61K31/4166;A61K31/4184;A61K31/4412;A61K31/443;A61K31/465;A61K31/497;A61K31/498;A61K31/501;A61K31/505;A61K31/517;A61P1/04;A61P3/10;A61P7/00;A61P9/10;A61P11/06;A61P17/00;A61P19/02;A61P25/00;A61P29/00;A61P37/06;C07D213/30;C07D213/64;C07D215/02;C07D235/04;C07D239/36;C07D317/60;C07D405/12;C07D409/14 |
主分类号 |
C07C217/48 |
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