| 摘要 |
The invention relates to anthranilic acid amide derivatives of formula I
wherein Ar is represented by the subformula I a
wherein R a represents H or lower alkyl, and R 1 represents H or perfluoro lower alkyl, R 2 represents H, halogen, C 2 -C 7 alkyl, C 2 -C 7 alkenyl or lower alkynyl;
or Ar is represented by the subformula I b , and
R 1 represents perfluoro lower alkyl, and R 2 represents bromo, iodo, C 2 -C 7 alkyl, C 2 -C 7 alkenyl or lower alkynyl, or R 1 represents H, and R 2 represents fluoro, bromo, indo, ethyl, C 5 -C 7 alkyl, C 2 -C 7 alkenyl or lower alkynyl;
to N-oxides and tautomers thereof, and to salts of such anthranilic acid amides, its N-oxides and tautomers; to processes for their preparation; to their application in the treatment of the human or animal body, to the use thereof - alone or in combination with one or more other pharmaceutically active compounds - for the treatment especially of a neoplastic disease, such as a tumor disease, of retinopathy or age-related macular degeneration; to a method for the treatment of such diseases in animals; and to the use of such a compound - alone or in combination with one or more other pharmaceutically active compounds - for the manufacture of a pharmaceutical preparation for the treatment of a neoplastic disease, of retinopathy or age-related macular degeneration. |
