发明名称 |
Melanocortin-3 receptor deficient cells, non-human transgenic animals and methods of selecting compounds which regulate body weight |
摘要 |
Cells and non-human transgenic animals have been engineered to be deficient in the gene encoding the melcanocortin-3 receptor protein (MC-3R). MC-3R deficient transgenic animals have increased fatmass and reduced lean body mass, showing that the MC-3R protein is involved in the regulation of body fat and muscle mass. These MC-3R deficient transgenic animals can be used to select for and test potential modulators of MC-3R. This data allows for methods of screening for MC-3R modulators which effect body weight and associated methods of treating various disorders associated with inappropriate regulation of body weight. The disclosure also relates to a MC-3R/MC-4R double knockout mouse which can be used to select for and test potential modulators (e.g., agonists or antagonists) of MC-3R and/or MC-4R. It is shown that MC-3R serves a non-redundant role, when compared to MC-4R, in the regulation of energy homeostasis.
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申请公布号 |
US7321074(B1) |
申请公布日期 |
2008.01.22 |
申请号 |
US20000129599 |
申请日期 |
2000.11.09 |
申请人 |
MERCK & CO., INC. |
发明人 |
VAN DER PLOEG LEONARDUS H. T.;CHEN HOWARD Y.;CHEN AIRU S. |
分类号 |
A01K67/027;C12N5/00;C12N5/06;C12N5/10 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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地址 |
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