发明名称 |
Crystalline form IV of agomelatine, a process for its preparation and pharmaceutical compositions containing it |
摘要 |
Crystalline form IV of agomelatine ((I); N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide) is new. Crystalline form IV of agomelatine having powder X-ray diffraction diagram, measured using a diffractometer (copper anticathode) and expressed in terms of inter-planar distance d (17.524-3.190 A[deg]), Bragg's angle 2 theta (5.04-27.95 degree), intensity and relative intensity (6-100 percentage with respect to the most intense), is new. Independent claims are included for: (1) the preparation of (I); and (2) a composition comprising (I) and, inert and non-toxic carriers. ACTIVITY : Hypnotic; Tranquilizer; Antidepressant; Cardiovascular-Gen.; Sedative; Muscular-Gen.; Immunomodulator; Neuroleptic; Anorectic; Anticonvulsant; Antidiabetic; Antiparkinsonian; Nootropic; Antimigraine; Neuroprotective; Endocrine-Gen.; Contraceptive; Cytostatic. MECHANISM OF ACTION : Melatoninergic receptor agonist. |
申请公布号 |
ZA200606455(B) |
申请公布日期 |
2007.12.27 |
申请号 |
ZA20060006455 |
申请日期 |
2006.08.03 |
申请人 |
LES LABORATOIRES SERVIER |
发明人 |
COQUEREL, GURARD;LINOL, JULIE;SOUVIE, JEAN-CLAUDE |
分类号 |
A61K;A61K31/165;C07C;C07C217/60;C07C233/22;C07C233/60;C07C233/73 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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