发明名称 |
NOVEL PROCESS FOR MAKING HUMAN PAPILLOMAVIRUS VIRUS-LIKE PARTICLES WITH IMPROVED PROPERTIES |
摘要 |
<p>Human papillomavirus virus-like particles (VLPs) are subjected to various maturation conditions, including incubation at higher temperatures, exposure to soluble metals or thios-oxidation. The resultant matured VLPs are more stable, and can be used to make a vaccine formulation with increased shelf life and higher potency.</p> |
申请公布号 |
EP1223976(B1) |
申请公布日期 |
2007.12.05 |
申请号 |
EP20000970770 |
申请日期 |
2000.10.11 |
申请人 |
MERCK & CO., INC. |
发明人 |
ZHAO, QINJIAN;WU, SHILU;MANGER, WALTER;GADAM, SHISHIR |
分类号 |
A61K39/12;C12N7/00;A61K47/42;A61K47/48;A61P15/00;A61P31/20;A61P35/00;C07K14/025;C12N7/02;C12N7/04;C12N7/06;C12N15/37;C12Q1/68;C12Q1/70 |
主分类号 |
A61K39/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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