COMPOSITIONS AND METHODS FOR THE DIRECT THERAPY OF TUMORS

摘要

The present invention provides methods for the treatment of tumors, such as spinal metastases, using compositions that permit the introduction of chemotherapeutics intratumorally while concurrently visualizing the procedure. Thus, in certain embodiments, the invention concerns a composition comprising a chemotherapeutic, an alcohol and an iodinated contrast agent (e.g., iodouracil) that may be introduced into the tumor by direct injection through the aid of an imaging device, such as a CT scanner, x-ray machine, fluoroscope or the like. The ability to visualize drug solution permits the faithful introduction of the drug directly into the tumor, as opposed to surrounding tissues, which is enabled through the use of the contrast medium.