摘要 |
The present invention relates to novel human coagulation Factor Vila variants having substitutions of one or more amino acids at a position selected from the group consisting of position 172, 173, 175, 176, 177, 196, 197, 198, 199, 200, 203, 235, 237, 238, 239, 240, 286, 287, 288, 289, 290, 291, 292, 293, 294, 295, 297, 299, 319, 320, 321, 327, 341, 363, 364, 365, 366, 367, 370, 373 corresponding to amiino acid positions of SEQ ID NO:1 and wherein said Factor VII polypeptide exhibits increased resistance to inactivation by an endogenous inhibitor of said FVII polypeptide relative to wild- type human FVIIa. |
申请人 |
NOVO NORDISK HEALTH CARE AG;OESTERGAARD, HENRIK;OLSEN, OLE, HVILSTED;LARSEN, KATRINE, SKAARUP;STENNICKE, HENNING |
发明人 |
OESTERGAARD, HENRIK;OLSEN, OLE, HVILSTED;LARSEN, KATRINE, SKAARUP;STENNICKE, HENNING |