发明名称 |
ANTIBODY FOR ASSAY OF ADAMTS13 ACTIVITY AND METHOD OF ACTIVITY ASSAY |
摘要 |
The subject of the present invention is to provide a useful antibody for measuring ADAMTS13 activity, in particular, a monoclonal antibody and a method for measuring ADAMTS13 activity. Further, another subject of the present invention also is to provide a monoclonal antibody which has specific reactivity to an antigenic determinant site produced by reacting ADAMTS13 with VWF that is a substrate or a partial peptide of VWF that is a potential substrate, but has no specific reactivity to the complete VWF molecule, and a use of the antibody of interest. Those subjects were achieved by succeeding in obtaining a monoclonal antibody (anti-N-10 monoclonal antibody) which has specific reactivity to a cleavage site that is cleavable by ADAMTS13 in the partial peptide of VWF, and further by finding a method for measuring ADAMTS13 activity using the monoclonal antibody of interest.
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申请公布号 |
EP1852442(A1) |
申请公布日期 |
2007.11.07 |
申请号 |
EP20060712413 |
申请日期 |
2006.01.26 |
申请人 |
JAPAN CLINICAL LABORATORIES, INC. |
发明人 |
KATO, SEIJI;HIURA, HISAHIDE;FUJIMURA, YOSHIHIRO;MATSUMOTO, MASANORI |
分类号 |
C07K16/18;C12N15/07;G01N33/53 |
主分类号 |
C07K16/18 |
代理机构 |
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主权项 |
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地址 |
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