| 摘要 |
Novel monogalactosyldiacylglycerol compounds isolated from Sargassum Thunbergii are provided which shows anti-fungal activity on Candida albican and contains both alpha-linoleic acid and eicosapentaenoic acid(EPA). A [(2S)-1-O-(5Z,8Z,11Z,14Z,17Z -eicosapentaenoyl)-2-O-(9Z,12Z,15Z-octadecatrienoyl)-3-O-beta-Dgalactopyranosyl-sn-glycerol] is represented by the formula(1). A (2S)-1-O-(9Z,12Z,15Z-octadecatrienoyl)-2-O-(6Z,9Z,12Z,15Z-octadecatetraenoyl)-3-O-beta-D-galactopyranosyl-sn-glycerol is represented by the formula(2). A method for preparing the monogalactosyldiacylglycerol compound comprises the steps of: (a) after mixing cut Sargassum Thunbergii with methanol in a weight ratio of 1:1-1:3 and leaving it for 48-72 hours, filtering it; (b) concentrating the methanol filtrate under reduced pressure and adding a mixture solution of butanol and water in a weight ratio of 1:1 thereto; (c) concentrating solvent of the butanol layer under reduced pressure and adding a mixture solution consisting of methanol and water in a weight ratio of 15:85 and normal hexane thereto; and (d) concentrating solvent of the methanol layer under reduced pressure and isolating the desired product through a reverse silica flash chromatography.
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