发明名称 |
Polymer-Conjugated Glycosylated Neublastin |
摘要 |
The following class of molecule is disclosed: a dimer containing a first neublastin polypeptide and a second neublastin polypeptide, wherein: (a) at least one of the polypeptides is glycosylated; (b) at least one of the polypeptides is conjugated at its N-terminus to a water-soluble synthetic polymer; and (c) neither of the polypeptides is conjugated to a water-soluble synthetic polymer at a position other than the N-terminus. Such dimers possess the biological activity of wild-type neublastin while displaying enhanced serum half-life and enhanced potency relative to wild-type neublastin.
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申请公布号 |
US2007238650(A1) |
申请公布日期 |
2007.10.11 |
申请号 |
US20040553710 |
申请日期 |
2004.04.16 |
申请人 |
SAH DINAH W;PEPINSKY R BLAKE;ROSSOMANDO ANTHONY |
发明人 |
SAH DINAH W.;PEPINSKY R. BLAKE;ROSSOMANDO ANTHONY |
分类号 |
A61K38/18;C07K14/475;C12N;C12N15/00 |
主分类号 |
A61K38/18 |
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