PHOSPHORIC ACID SALT OF A DIPEPTIDYL PEPTIDASE-IV INHIBITOR

摘要

The dihydrogenphosphate salt of 4-oxo-4-[3-(trifluoromethyl)-5,6- dihydro[1,2,4]triazolo[4,3-alpha]pyrazin-7(8H)-yl]-1-(2,4,5- trifluorophenyl)butan-2-amine is a potent inhibitor of dipeptidyl peptidase- IV and is useful for the prevention and/or treatment of non-insulin dependent diabetes mellitus, also referred to as type 2 diabetes. The invention also relates to a crystalline monohydrate of the dihydrogenphosphate salt as well as a process for its preparation, pharmaceutical compositions containing thi s novel form and methods of use for the treatment of diabetes, obesity, and hi gh blood pressure.