摘要 |
<p>This invention is directed to methods for preventing, treating, reversing, inhibiting or arresting epilepsy and epileptogenesis in a subject comprising administering to the subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of Formula (I) and Formula (II), or a pharmaceutically acceptable salt or ester thereof,: Formula (I) Formula (II) wherein phenyl is substituted at X with one to five halogen atoms selected from the group consisting of fluorine, chlorine, bromine and iodine; and, R<sub>1</sub>, R<sub>2</sub>, R<sub>3</sub>, R<sub>4</sub>, R<sub>5</sub> and R<sub>6</sub> are independently selected from the group consisting of hydrogen and C<sub>1</sub>-C<sub>4</sub> alkyl; wherein C<sub>1</sub>-C<sub>4</sub> alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of halogen, C<sub>1</sub>-C<sub>4</sub> alkyl, C<sub>1</sub>-C<sub>4</sub> alkoxy, amino, nitro and cyano).</p> |
申请人 |
JOHNSON & JOHNSON |
发明人 |
ZHAO, BOYU;CHOI, YONG MOON;GORDON, ROBERT;NOVAK, GERALD P.;PLATA-SALAMAN, CARLOS R.;TWYMAN, ROY E.;WHITE, H. STEVE |