METHODS AND SYSTEMS FOR EVALUATING HEALTH RISK FACTORS BY MEASUREMENT OF DNA DAMAGE AND DNA REPAIR
摘要
Disclosed are methods for measuring the effects of environmental, physiological, or lifestyle variables on DNA damage and DNA repair activity as well as the use of measurements of DNA damage and DNA repair activity to predict increased risk for disease. Embodiments of the methods involve the use of a combination of assays to measure DNA damage and DNA repair activity in an individual and comparing these measurements to suitable controls using the selected assays for normal healthy individuals of varying ages. In other embodiments, the methods may comprise a comparison of DNA damage levels to DNA repair levels to obtain an apparent net measurement of DNA damage accumulation.
申请公布号
WO2007103116(A2)
申请公布日期
2007.09.13
申请号
WO2007US05269
申请日期
2007.03.02
申请人
LABORATORY CORPORATION OF AMERICA HOLDINGS;ALBRECHT, JEFFREY;GALA, FRANCOISE;CONRAD, ANDREW;GRANT, RUSSELL
发明人
ALBRECHT, JEFFREY;GALA, FRANCOISE;CONRAD, ANDREW;GRANT, RUSSELL