发明名称 |
OLIGONUCLEOTIDE-PEPTIDE CONJUGATE WITH ABILITY TO CLEAVE RNA PHOSPHODIESTER BONDS IN 5'GpN3' SEQUENCES |
摘要 |
FIELD: bioorganic chemistry. ^ SUBSTANCE: disclosed is oligonucleotide-peptide conjugate of general formula 3'TTCTCTAGG5'-dRib-dRib-dRib-N-terminal-Leu-Arg-Leu-Arg-Leu-Arg-Arg-Gly-NH2-C-terminal (wherein T is thymine residue; C is cytosine residue; A is adenosine residue; G is guanosine residue; drib is deoxyribose residue; Leu is leucine residue; Arg is arginine residue; Gly is glycine residue). Said conjugate cleaves phosphodiester bonds in single-stranded RNA sites in 5'GpN3' (wherein G is guanosine; N is any ribonucleotide) sequences only. ^ EFFECT: new conjugate being functional analog of T1 ribonuclease. ^ 3 dwg, 4 ex |
申请公布号 |
RU2305108(C1) |
申请公布日期 |
2007.08.27 |
申请号 |
RU20060109836 |
申请日期 |
2006.03.27 |
申请人 |
INSTITUT KHIMICHESKOJ BIOLOGII I FUNDAMENTAL'NOJ MEDITSINY SIBIRSKOGO OTDELENIJA ROSSIJSKOJ AKADEMII NAUK (SO RAN) |
发明人 |
MIRONOVA NADEZHDA L'VOVNA;PYSHNYJ DMITRIJ VLADIMIROVICH;SHTADLER DMITRIJ VLADIMIROVICH;ZENKOVA MARINA ARKAD'EVNA;VLASOV VALENTIN VIKTOROVICH |
分类号 |
C07K7/06;C07H21/04;C12N9/22;C12N15/11;C12N15/55;C12Q1/68 |
主分类号 |
C07K7/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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