| 发明名称 |
METHODS FOR REDUCING OR ELIMINATING ALPHA-MANNOSIDASE RESISTANT GLYCANS IN THE PRODUCTION OF GLYCOPROTEINS |
| 摘要 |
The present invention provides methods to reduce or eliminate a-mannosidase resistant glycans on glycoproteins in yeast. The reduction or elimination of a-mannosidase resistant glycans on glycoproteins results from the disruption of the newly isolated P. pastoris AMR 2 gene encoding ß1,2-mannosyltransferase. The present invention also discloses novel genes, polypeptides, antibodies, vectors and host cells relating to a-mannosidase resistance on glycans. |
| 申请公布号 |
WO2005106010(A3) |
申请公布日期 |
2007.08.16 |
| 申请号 |
WO2005IB51415 |
申请日期 |
2005.04.29 |
| 申请人 |
GLYCOFI, INC.;BOBROWICZ, PIOTR |
发明人 |
BOBROWICZ, PIOTR |
| 分类号 |
C07H21/04;C07K16/00;C12N1/19;C12N9/10;C12N15/00;C12N15/80;C12N15/82;C12P21/00;C12P21/06 |
主分类号 |
C07H21/04 |
| 代理机构 |
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