ACRYLAMIDE DERIVATIVES AS ANTIBIOTIC AGENTS

摘要

The present invention is directed to antibacterial compounds formula (I), wherein, independently for each occurrence, A is a monocyclic ring of 4-7 atoms containing 0-2 heteroatoms, a bicyclic ring of 8-12 atoms containing 0-4 heteroatoms or a tricyclic ring of 8-12 atoms containing 0-6 heteroatoms wherein the rings are independently aliphatic, aromatic, heteroaryl or heterocyclic in nature, the heteroatoms are selected from N, S or O and the rings are optionally substituted with one or more groups selected from CM alkyl, OR", CN, OCF₃, F, Cl, Br, I; wherein R" is H, alkyl, aralkyl, or heteroaralkyl; R is formula (II), (III), (IV), (V), (VI), (VII) wherein, independently for each occurrence, R₁ is H, alkyl, or aryl, or R₁ and R₂ taken together form a fused ring; R₂ is H, alkyl, or aryl, or R₂ and R₁ taken together form a fused ring, or R₂ and R₃ taken together form a spirocyclic ring; R₃ is H, alkyl, or aryl, or R₃ and R₂ taken together form a spirocyclic ring; R₄ is H, alkyl, aryl, hydroxy substituted alkyl, or -C(O)ONa; R₅ is H, alkyl, or aryl; R₆ is H, alkyl, or aryl; and L₁ is O or H₂.