发明名称 |
1,1-Disubstitutedcycloalkyl-, glycinamidyl-, sulfonyl-amidino-, and tetrahydropyrimidinyl-containing diaminoalkyl, beta-aminoacids, alpha-aminoacids and derivatives thereof as factor Xa inhibitors |
摘要 |
The present application describes 1,1-disubstitutedcycloalkyl-, glycinamidyl-, sulfonyl-amidino-, and tetrahydropyrimidinyl-containing diaminoalkyl, beta-aminoacids, alpha-aminoacids and derivatives thereof of Formula I: <?in-line-formulae description="In-line Formulae" end="lead"?>P-M-M<SUB>1</SUB>I<?in-line-formulae description="In-line Formulae" end="tail"?> or a stereoisomer or pharmaceutically acceptable salt or solvate form thereof, wherein M is a linear core. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
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申请公布号 |
US7250415(B2) |
申请公布日期 |
2007.07.31 |
申请号 |
US20040858084 |
申请日期 |
2004.06.01 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
QIAO JENNIFER X.;PINTO DONALD J. |
分类号 |
A61K31/5375;A01N37/18;A01N43/06;A01N43/36;A01N43/38;A61K31/165;A61K31/17;A61K31/38;A61K31/40;A61K31/404;A61K31/501;A61K31/505;A61K31/535;A61K31/54;A61K31/55;C07C233/40;C07D209/14;C07D265/30;C07D333/22;C07D409/12;C12N |
主分类号 |
A61K31/5375 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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