OXAZOLIDINONE-QUINOLONE HYBRIDS AS ANTIBACTERIAL COMPOUNDS

摘要

The invention relates to novel chimeric antibiotics of formula (I) Wherein R¹ is CH₂NHCOR⁵, heteroarylmethyl, heteroaryloxymethyl or heteroarylaminomethyl; R² is H, OH, OSO₃H, OPO₃H₂, OCH₂OPO₃H₂, OCOCH₂CH₂COOH, OCOR⁶; R³ is H or halogen; R⁴ is (C₁-C₃)alkyl, (C₁-C₃)haloalkyl or cycloalkyl; R⁵ is alkyl or haloalkyl; and R⁶ is the residue of a naturally occurring amino acid or of dimethylaminoglycine. These chimeric compounds are useful in the manufacture of medicaments for the treatment of infections (e.g. bacterial infections).