ARYL DIHYDRO-NAPHTHALENE COMPOUNDS, THEIR PREPARATION AND THEIR USE AS AKT INHIBITOR FOR THE PREVENTION AND TREATMENT OF CANCER

摘要

Aryl dihydro-naphthalene lignan derivatives of the following formula with Akt inhibiting activity, and the method of the said compounds and the pharmaceutical composition containing the compounds for treating cancer by inhibiting Akt activated channel. wherein X is C=O, C=S, C N, methylene or alkenyl; Y is hydrogen, hydroxyl, amino or alkyl, or Y group is absent; R<SUB>1</SUB> and R<SUB>2</SUB> are respectively hydrogen, alkyl, alkenyl, glucosyl, glucuronosyl, acyl or aryl; R<SUB>3 </SUB>is hydrogen or glucosyl; R<SUB>4 </SUB>is methoxyl or hydrogen; R<SUB>5</SUB>is methoxyl or hydrogen; the hydrogen atoms on the 3-positon and the 4-position of the nuclear parent are (3R, 4S).