发明名称 |
Inhibitor for the formation of y-secretase complex |
摘要 |
It is intended to provide an inhibitor for the formation of a gamma-secretase complex which comprises a cholesterol synthesis inhibitor or a protein geranylgeranylation regulator as the active ingredient; and use of a cholesterol synthesis inhibitor or a protein geranylgeranylation regulator for producing the same. It is also intended to provide a method of screening a substance having an effect of inhibiting the formation of an active complex of gamma-secretase which comprises assaying the activity of inhibiting cholesterol synthesis or quantifying cholesterol accumulated in lipid rafts in cells. It is also intended to provide a method of screening a cholesterol synthesis inhibitor, a protein geranylgeranylation regulator or an HMG-CoA reductase inhibitor which comprises assaying the effect of inhibiting the formation of an active complex of gamma-secretase. Moreover, it is intended to provide a method of screening an effect of a test substance on gamma-secretase which comprises measuring the distribution of constituents (niscastrin, APH-1, Pen-2 and so on) required by gamma-secretase for the formation of its active complex in cells.
|
申请公布号 |
US2007161700(A1) |
申请公布日期 |
2007.07.12 |
申请号 |
US20040584415 |
申请日期 |
2004.12.28 |
申请人 |
NISSAN CHEMICAL INDUSTRIES, LTD. |
发明人 |
URANO YASUOMI;HAMAKUBO TAKAO;KODAMA TATSUHIKO |
分类号 |
A61K31/401;A61K31/22;A61K31/366 |
主分类号 |
A61K31/401 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|