MULTIPOLE ION GUIDE ION TRAP MASS SPECTROMETRY

摘要

A Time-Of-Flight mass analyzer includes a multipole ion guide (16) located in the ion flight path between the ion source (1) and the flight tube (42) of the Time-Of-Flight mass analyzer. In one preferred embodiment, a Time-Of-Flight (TOF) mass analyzer is configured such that a multipole ion guide is positioned in the ion path between the ion source and the ion pulsing region (30) of the TOF mass analyzer. The multiple ion guide electronics and the ion guide entrance and exit electrostatic lenses (26, 27 and 28) are configured to enable the trapping or passing through of ions delivered from an atmospheric pressure ion source. The ion guide electronics can be set to select the mass to charge (m/z) range of ions which can be successfully transmitted or trapped in the ion guide. All or a portion of the ions with stable ion guide trajectories in transmission or trapping mode can then undergo Collisional Induced Dissociation (CID) using one of at least three techniques. The multipole ion guide is used for ion transmission, trapping and fragmentation can reside in one vacuum pumping stage (138) or can extend continuously into more than one vacuum pumping stage (18, 19).