METHODS FOR IDENTIFYING CHEMOTHERAPEUTIC RESISTANCE IN NON-HEMATOPOIETIC TUMORS

摘要

Disclosed are methods for detecting adriamycin resistance in a test neoplastic cell from a non-hematological cancer. The methods include detecting a level of pl6 expression in the test neoplastic cell of a given origin or cell type, and comparing the level of pl6 expression detected in the test neoplastic cell to the level of pl6 expression in a nonresistant neoplastic cell of the same origin or cell type, wherein the test neoplastic cell is adriamycin resistant if the level of pl6 expression is greater than the level of pl6 expression in the nonresistant neoplastic cell of the same origin or cell type. Also disclosed are therapeutic compositions comprising an agent that inhibits pl6 and a pharmaceutically acceptable carrier.