, ??-UNSATURATED ESTERS AND ACIDS BY STEREOSELECTIVE DEHYDRATION.

摘要

There are provided by the present invention certain pyrazole based CCK-1 receptor modulatorswhich have the general formula: wherein Ar is an aromatic or heteroaromatic group,X is a hydrocarbon linker, Y is a bond or hydrocarbon linker and R1, R2,R3, R4 and R5 are certain organic substituents,methods for making the same, and stereoselective dehydration methods for generallymaking , a-unsaturated esters, acids and their derivatives.