发明名称 |
Diagnostic and therapeutic use of steroidogenic acute regulatory protein for neurodegenerative diseases |
摘要 |
The present invention discloses the differential expression of the steroidogenic acute regulatory protein (StAR) gene in specific brain regions of Alzheimer's disease patients. Based on this finding, this invention provides a method for diagnosing or prognosticating a neurodegenerative disease, in particular Alzheimer's disease, in a subject, or for determining whether a subject is at increased risk of developing such a disease. Furthermore, this invention provides therapeutic and prophylactic methods for treating or preventing Alzheimer's disease and related neurodegenerative disorders using the StAR gene and gene products. A method of screening for modulating agents of neurodegenerative diseases is also disclosed.
|
申请公布号 |
US2007118913(A1) |
申请公布日期 |
2007.05.24 |
申请号 |
US20030517439 |
申请日期 |
2003.06.05 |
申请人 |
HESTERKAMP THOMAS;VON DER KAMMER HEINZ;KRAPPA RALF;POHLNER JOHANNES |
发明人 |
HESTERKAMP THOMAS;VON DER KAMMER HEINZ;KRAPPA RALF;POHLNER JOHANNES |
分类号 |
A01K67/027;C07K14/705;C12Q1/68;G01N33/567 |
主分类号 |
A01K67/027 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|